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Uracil DNA glycosylase (UNG) loss enhances DNA double strand break formation in human cancer cells exposed to pemetrexed1Department of Pathology, Case Western Reserve University School of Medicine,scarpe hogan, 10900 Euclid Avenue, Cleveland,air jordan shop, OH 44106, USA2Department of Genetics and Genome Sciences,peuterey outlet roma, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA3Case Comprehensive Cancer Center,vetement hollister pas cher, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106, USA4Department of Medicine, Division of Hematology Case Western Reserve University School of Medicine, 2103 Cornell Road, Cleveland,tiffany outlet milano, OH 44106, USACorrespondence: SL Gerson,doudoune moncler pas cher femme, Department of Medicine,jordan pas cher, Case Comprehensive Cancer Center, 111000 Euclid Avenue,piumini woolrich outlet, Wearn 151,hogan prezzi, Cleveland,nike tn officiel, OH 44106, USA. Uracil DNA glycosylase (UNG) catalyzes the excision of uracil from DNA and initiates DNA base excision repair (BER). Based on these findings we propose that pemetrexed induced uracil misincorporation is genotoxic,moncler piumini, contributing to replication fork instability, DSB formation and ultimately cell death..
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